The clinical benefits of PRP in enhancing healing of persistent wounds, especially those resulting from illness rather than trauma, are significant. Pressure and diabetic ulcers are classic examples. Wound healing is a complex and dynamic process. Normally when a wound begins healing the eventual result is complete wound closure. Healing of acute and chronic wounds, though, can be impaired by factors like separate but simultaneous illnesses or infection, combined with a failure of the vascular system to deliver sufficient healing and regrowth agents to the wound site.
Non-healing wounds need outside assistance – beyond normal wound care – to restart the healing process. By delivering agents like cytokines, growth factors, chemokines, and a fibrin scaffold to the wound, platelet rich plasma stimulates wound healing.
Background to Platelet Rich Plasma (PRP)
Wound healing is a dynamic, interactive process involving multiple cells and proteins interacting sequentially in an integrated series of cellular, physiologic, biochemical, and molecular events and this delicate balance can be interrupted by a number of factors including the presence of infection, ischaemia and extensive trauma. According to Sanchez-Gonzales et al (2012), these factors may increase the level of pro-inflammatory cytokines, triggering an increase in the cellular levels of metalloproteinases, and the resultant decrease in the tissue growth factors, which may result in delayed wound healing.
The Introduction of the clinical paper by Martin, Constantinides and Sarkar 2014  aptly demonstrates the need for this technology:
“Non-healing foot wounds are a significant source of morbidity and mortality in diabetic patients Studies have suggested that 2.5% of diabetics will have a foot ulcer at any one time, which equates to approximately 80,000 people. Foot ulceration is the major contributing factor to the 30 times increased risk of amputation in diabetic patients compared to the general population. Encouraging healing of diabetic foot wounds with rapid coverage of subcutaneous tissues decreases this associated morbidity and cost. This healing is severely impaired for multifactorial reasons in diabetic patients.”